تفاصيل الرسالة العلمية

New series of nicotinonitrile derivatives 45(a-g), have been synthesized by alkylation of 2(1H)-pyridone derivatives 44(a-g) using chloroacetonitrile. The new nicotinonitriles 45(a-g) were successfully transformed to 4-(aryl)-6-(2,5-dichlorothiophen-3-yl)-2-methoxynicotinonitrile 47(a-g) using sodium methoxide. All new compounds 45(a-g) and 47(a-g) were characterized by different spectroscopic techniques such as IR, 1H NMR, 13C NMR, 2D-NMR and X-ray single crystal measurements. The new compounds 45(a-g) and 47(a-g) were evaluated with respect to their antioxidant and antimicrobial activities. The study showed that compounds 45e, 45f, 47a, 47d, 47e and 47g, IC50 values ranging from 57.47 to 91.21 ?g/mL, exhibited a strong free radical scavenger compared to ascorbic acid. Compound 45f displayed strong activity against Coagulase-negative staphylococci (CONS) bacteria and Streptococcus species, also 45e exhibited notable activity against Streptococcus species