تفاصيل الرسالة العلمية

In the present work, a series of 1,2,4-triazole derivatives were designed as combretastatin A-4 analogues with 4-nitrophenyl group and different aliphatic alkyl substituents, the designed compounds were synthesized and characterized by FT-IR, 1H NMR and 13C NMR spectroscopy. The synthesized compounds were tested as anticancer agents against human laryngeal cancer (Hep-2) cell line, the cytoxicity of the synthesized compounds were evaluated by the treatment of human normal kidney (Vero) cell line. The obtained results revealed the compound (46c) which has n-propyl substituent is the most active one and has lowest cytotoxicity against normal cells, this compound has the lowest IC50 value within the tested series, consequently compound (46c) could be considered as promising anticancer agent and good candidate for further pharmacological studies