تفاصيل الرسالة العلمية

This study used a new analytical method for analyzing and determining Rosuvastatin [RST] and Rosuvastatin ? Lactone as well verifying the validity of the method via HPLC . It also studied the kinetic degradation for Rosuvastatin and Rosuvastatin-Lactone at thermal condition . The study showed that the new analytical method is sensitive, simple and able to determine the Rosuvastatin [RST] and Rosuvastatin-Lactone . According to the practical experiments , it was observed that the method of the USP was inappropriate to determine Rosuvastatin impurity . In contrary , it was noticed positive results regarding to lactone impurity . The kinetic degradation showed that the Rosuvastatin [RST] peak appeared at retention time 2.3min. and Rosuvastatin -lactone peak appeared at retention time 5.3 min.. Moreover , the effect of solvent on the Rosuvastatin degradation and the reaction equilibrium